Chemistry Biology

Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data

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Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data

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Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data

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Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data

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Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data

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Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Molecular Sequence Data

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An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Organic Chemistry / Enzyme Inhibitors / Cell line / Humans / Drug Resistance / L-asparaginase / Tight Binding / Cell Proliferation / Chemistry Biology / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Fghfgh / L-asparaginase / Tight Binding / Cell Proliferation / Chemistry Biology / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Fghfgh

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Antifungal Tradecraft by Cholesterol Oxidase

Organic Chemistry / Catalysis / Statistical Analysis / Protein Engineering / High throughput screening / Cholesterol / Pseudomonas / Enzyme / Substrate Specificity / Antifungal Agents / Chemical Properties / Chemistry Biology / Ergosterol / Function Space / Enzymatic Activity / Biochemistry and cell biology / Cholesterol / Pseudomonas / Enzyme / Substrate Specificity / Antifungal Agents / Chemical Properties / Chemistry Biology / Ergosterol / Function Space / Enzymatic Activity / Biochemistry and cell biology

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Human Symbiont Bacteroides thetaiotaomicron Synthesizes 2-Keto-3-Deoxy-D-Glycero-D- Galacto-Nononic Acid (KDN)

Organic Chemistry / Symbiosis / Humans / Chemistry Biology / Biochemistry and cell biology / Molecular Structure

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Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Organic Chemistry / Malaria / Saccharomyces cerevisiae / Humans / Sequence alignment / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology / Escherichia coli / Mice / Female / Animals / Sesquiterpenes / Plasmodium falciparum / Antimalarials / Protozoan Proteins / Cell Proliferation / Amino Acid Sequence / Chemistry Biology / Recombinant Proteins / Protein Binding / Biochemistry and cell biology

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A new enzyme superfamily ? the phosphopantetheinyl transferases

Organic Chemistry / Sequence alignment / Escherichia coli / Enzyme / Substrate Specificity / Amino Acid Sequence / Chemistry Biology / Catalytic Activity / Biochemistry and cell biology / Amino Acid Sequence / Chemistry Biology / Catalytic Activity / Biochemistry and cell biology

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Nanomolar CFTR Inhibition by Pore-Occluding Divalent Polyethylene Glycol-Malonic Acid Hydrazides

Organic Chemistry / Magnetic Resonance Spectroscopy / Patch-clamp and imaging techniques / Humans / Mice / Animals / Polyethylene Glycol / Rats / Stilbenes / Cholera toxin-b / Chemistry Biology / Malonates / Polyethylene Glycols / Biochemistry and cell biology / Animals / Polyethylene Glycol / Rats / Stilbenes / Cholera toxin-b / Chemistry Biology / Malonates / Polyethylene Glycols / Biochemistry and cell biology

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Nanomolar CFTR Inhibition by Pore-Occluding Divalent Polyethylene Glycol-Malonic Acid Hydrazides

Organic Chemistry / Magnetic Resonance Spectroscopy / Patch-clamp and imaging techniques / Humans / Mice / Animals / Polyethylene Glycol / Rats / Stilbenes / Cholera toxin-b / Chemistry Biology / Malonates / Polyethylene Glycols / Biochemistry and cell biology / Animals / Polyethylene Glycol / Rats / Stilbenes / Cholera toxin-b / Chemistry Biology / Malonates / Polyethylene Glycols / Biochemistry and cell biology

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A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic

Organic Chemistry / Catalysis / Kinetics / Mitochondria / Manganese / Macromolecular X-Ray Crystallography / Animals / Superoxide Dismutase / Ascorbic Acid / Rats / Biomimetic materials / Molecular Conformation / Chemistry Biology / Organometallic Compounds / Oxidation-Reduction / Pulse Radiolysis / Superoxides / Biochemistry and cell biology / Macromolecular X-Ray Crystallography / Animals / Superoxide Dismutase / Ascorbic Acid / Rats / Biomimetic materials / Molecular Conformation / Chemistry Biology / Organometallic Compounds / Oxidation-Reduction / Pulse Radiolysis / Superoxides / Biochemistry and cell biology

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